Doxy-PEP

Reduce Risk of STIs like Chlamydia and Syphilis.

Doxy-PEP

Reduce Risk of STIs like Chlamydia and Syphilis.

Learn all the facts about Doxy-PEP (the pros, the cons) to make the right decision for you.

What is Doxy-PEP?

Doxy-PEP is taking an antibiotic known as doxycycline within 72 hours after sexual activity.

This can reduce the risk of acquiring chlamydia, syphilis and possibly gonorrhea. Some studies have suggested it can reduce the risk of some STIs by approximately 60-80%.

But… there are some concerns on it’s use around antibiotic resistance, possible impact on our gut health, and whether it should have widespread use.

Should everyone go on Doxy-PEP?

Studies looking into the use of Doxy-PEP have found it most beneficial in people who have a history of frequent and/or recent STIs.

Considering the lack of effectiveness against gonorrhea (see below) and the ability to still possibly get chlamydia and syphilis on it, there is a risk versus benefit consideration to start Doxy-PEP.

A significant concern is possible increased risk for antibiotic resistance.

This is where taking Doxy-PEP more regularly could potentially lead to doxycycline resistance making it ineffective if ever needed for the treatment of STIs.

Responsible care providers know all of this and do not advocate automatic mass use of Doxy-PEP.

How is Doxy-PEP typically taken?

A typical prescription for Doxy-PEP is taking two tablets (200mg) within 72 hours after a possible risk exposure.

For example, if a person had sexual activity on a Monday at 12pm they would need to take their dose before Thursday at 12pm.

What are the Side Effects?

The medication is generally well tolerated, but like most antibiotics may cause stomach upset or possibly diarrhea.

There are concerns that with more frequent antibiotic use this can potentially impact the regular bacterial balance in our gastrointestinal tract. More long term data is needed on this.

The medication is taken with a lot of water and a person should not to lie down for at least 30 minutes after taking it. This reduces the risk of throat irritation (or rarely ulceration).

Doxycycline may also make you more sensitive to sunlight (caution re: travel, tanning) and it should be spaced apart from multivitamins, minerals, and antacids.

So about gonorrhea…

Some earlier studies suggested Doxy-PEP may provide some protection from acquiring gonorrhea.

However, some additional investigations have found it may provide zero additional protection.

This is not surprising as many patients on Doxy-PEP with our clinic still are acquiring gonorrhea.

So, essentially, a person could be on Doxy-PEP to try to prevent an infection, and then still need additional antibiotics for treatment afterwards anyway.